In 1952, he was the first recipient of the francis gilman blake award from yale for outstanding teaching. Apr 07, 2017 best biliary drainage option in advanced klatskin tumor the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. While there is no official known cause for klatskin tumors in the bile duct, there are some risk factors that have been associated with a small percentage of those diagnosed because they are known to cause biliary inflammation and may be related to klatskin tumor formation. Cholangiocarcinoma is a rare tumor with a broad range of pathologic and clinical. It was his dream to create a histological atlas of diseases of the liver, an ambition brought to fruition in 1993 by harold conn, his first fellow and longtime collaborator at yale. Cholangiocarcinoma survival rate, prognosis, foundation. Cholangiocarcinoma is the second most common primary malignancy of the liver. It poses unique problems in the diagnosis and management because of its anatomical location.
Local resection of hilar tumor, klatskin zollingers. Findings are concerning for neoplastic disease klatskin s tumor. Klatskin tumor is quite rare, more in male sex in age 60 years. Cholangiocarcinoma staging is dependent on whether the tumor is primarily intrahepatic icc, hilarperihilar klatskin, or extrahepatic tumor resection is currently the most optimal treatment and the ability of the tumor to infiltrate longitudinally and radially along the biliary tree necessitates aggressive resection strategies such as ipsilateral hepatectomy. This helps you give your presentation on brain cancer in a conference, a school lecture, a business proposal, in a webinar and business and professional representations the uploader spent hisher valuable. This neoplasia, which originates in the epithelium of the biliary ducts, or cholangiocarcinoma cc, represents 10% of hepatobiliary tumours and 2% of malignant tumours. This search will retrieve items that correspond to any of those words, ranking higher. Risk factors and clinical presentation of hepatobiliary carcinoma in patients with primary sclerosing cholangitis. Hi, my name is jackie and i was wondering if anyone out there knows anything about klatskin tumor. In addition to the liver, the composite allografts included various combina. Subsequently, a series of patients with this diagnosis was reported by klatskin in 1965. There is an enhancing soft tissue density within the common hepatic duct with postfocal dilation of the cbd measuring 1. Klatskin tumour a klatskin tumor or hilar cholangiocarcinoma cancer of the biliary tree occurring at the confluence of the right and left.
However, because the treatment with radiation and chemotherapy was not successful, he decided to undergo hyperthermia combined with chemotherapy as a second treatment option. Klatskin tumor is a term that was traditionally given to a hilar cholangiocarcinoma, occurring at the bifurcation of the common hepatic duct. If you continue browsing the site, you agree to the use of cookies on this website. Klatskin tumor genetic and rare diseases information. Biliary tumors cholangiocarcinoma and cancer of the gall bladder is the property of its rightful owner.
Listing a study does not mean it has been evaluated by the u. Clipping is a handy way to collect important slides you want to go back to later. More than 95% of all cancers of the biliary tree are adenocarcinomas. This requires mandatory en bloc liver resection and resection of the extrahepatic bile duct often together with vascular resection.
Worlds best powerpoint templates crystalgraphics offers more powerpoint templates than anyone else in the world, with over 4 million to choose from. Download fullsize image gerald klatskin 19101986 was born in new york city to a family of russian descent. I am 61 years old, married and we have two wonderful grownup sons. While there is no official known cause for klatskin tumors in the bile duct, there are some risk factors that have been associated with a small percentage of those diagnosed because they are known to cause biliary inflammation and may be related to klatskin tumor formation primary sclerosing cholangitis. Dec 28, 2019 jaundice is the most common manifestation of bile duct cancer and, in general, is best detected in direct sunlight. Limits of surgical resection for bile duct cancer fulltext. Aim to describe the surgical approaches currently applied in our centre and the impact of these strategies on outcome and criteria for resection. Hilar cholangiocarcinoma, also known as klatskin tumour, is the commonest type of cholangiocarcinoma. Klatskin tumor is a type of cancerous growth develops at the junction between right and left biliary duct from where main bile duct is formed. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Thirtyone variables were evaluated for prognostic significance. All types of cancerous growth in the biliary duct are termed as cholangiocarcinoma. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that.
A, longitudinal view of the common hepatic duct shows a tapered segment arrow consistent with tumor stricture. Methods data on klatskin tumors between 2004 and 20 was extracted from the surveillance, epidemiology and end results registry. Geographic alteration in lobar echotexture secondary to a klatskin tumor. Curative surgery in the form of major hepatic resection entails significant morbidity. Ppt biliary tumors cholangiocarcinoma and cancer of the. B, transverse image at the biliary confluence reveals an echogenic mass arrow at the bifurcation and dilated bile ducts in both lobes. Quadruplephase mdct of the liver in patients with suspected hepatocellular carcinoma. Patient with unresectable cholangiocarcinoma treated with. Prognosis for the patient depends on the size of the tumor at the time of diagnosis, whether the left and right bile ducts are also involved, and the patients general physical condition. During his undergraduate years at cornell he developed a keen interest in histology and in 1933 was awarded his m. The disease was named after gerald klatskin, who in 1965 described 15 cases and found some characteristics for this type of cholangiocarcinoma. A klatskin tumor or hilar cholangiocarcinoma is a cholangiocarcinoma cancer of the biliary tree occurring at the confluence of the right and left hepatic bile ducts. Differential diagnosis of sclerosing cholangiocarcinomas of the.
Klatskin tumors are are a type of cholangiocarcinoma that begins in an area called the hilum, where the left and right bile ducts join and leave the liver. Mark fraiman on april 20, 2016 in bile cancer, bile duct cancer if someone close to you, say a family member or friend, has recently been diagnosed with bile duct cancer, specifically involving klatskin tumors, you may be struggling with what to say or how best to help. A free powerpoint ppt presentation displayed as a flash slide show on id. In 73 of the resected patients 67%, all gross tumor was removed, while in 36 patients 33% gross tumor was left behind after resection. Our community leaders community leaders are active users that have been touched by the rare disease that they are a part of. In recent years, with the invention and development of the technology of mdct, increasing numbers of reports have been published on its use for preoperative assessment of liver tumors and pancreatic tumors 1, 2. Klatskins tumor, or perihilar cholangiocarcinoma involving the bifurcation of the hepatic duct, accounts for approximately 70% of all bile duct cancers. Presentation of the intrahepatic and partial extrahepatic bile ducts with their. Typically, these tumors are small, poorly differentiated, exhibit aggressive biologic behavior, and tend.
Klatskin s tumor, or perihilar cholangiocarcinoma involving the bifurcation of the hepatic duct, accounts for approximately 70% of all bile duct cancers. How to help a friend with a klatskin tumor diagnosis. Often there is hepatic lobar atrophy, biliary dilatation, and crowding. About 515% of specimens resected for presumed klatskin tumour prove not to be.
Mar 27, 2005 hi, my name is jackie and i was wondering if anyone out there knows anything about klatskin tumor. Powerpoint is the worlds most popular presentation software which can let you create professional brain tumor powerpoint presentation easily and in no time. Preoperative evaluation of resectability of klatskin tumor with 16mdct angiography and cholangiography original research. Ppt cholangiocarcinoma powerpoint presentation free to. This helps you give your presentation on brain tumor in a conference, a school lecture, a business proposal, in a webinar and business and professional representations. Hilar cholangiocarcinoma altemeier klatskin tumor 1, 2 is an uncommon malignant neoplasm, arising from the bile duct epithelium of the common hepatic duct or its first and second bifurcation. Klatskin tumor genetic and rare diseases information center. The patient is alive and has been under careful surveillance for about 5 months up to the time of this report. Customers affiliates powerpoint tutorial videotour infographics. Background surgical treatment of hilar cholangiocarcinoma klatskin tumours is difficult because of its central location in the liver hilum. Definition of cholangiocarcinoma cholangiocarcinoma is a rare tumor arising from the biliary epithelium and may occur anywhere along the biliary tree.
Of the 196 patients with klatskin tumors undergoing operative exploration, 8 4. Treatment ofhilar cholangiocarcinoma klatskin tumors. From my understanding, i thought that because of the strategic location of the klatskin tumor, it can cause obstruction and hence an earlier presentation by the patient with jaundice and thus these tmors can be resected with a much more reasonable and better prognosis compared to most cholangiocarcinomas. Preoperative evaluation of resectability of klatskin tumor. Last week my husband also 61 was diagnosed with a klatskin tumor. Typically, these tumors are small, poorly differentiated, exhibit aggressive biologic behavior, and tend to obstruct the intrahepatic bile ducts. But few reports of its use for the preoperative assessment of klatskin tumors are available. Treatment of hilar cholangiocarcinoma klatskin tumors with. Cholangiocarcinoma is an adenocarcinoma that arises from the bile duct epithelium. Bismuth classification for perihilar cholangiocarcinoma. There is prooved connection between this malignant tumor and primary sclerosis cholangitis autoimmune disease and parasitic infection in biliary ducts clonorchis sinensis and opisthorchis viverrini, both in southeast asia. Treatment ofhilar cholangiocarcinoma klatskin tumors with hepatic resection or transplantation shunzaburo iwatsuki, md, rho.
Having heard this klatskin name, i went online and discovered this forum. It is best evaluated by ultrasound prior to placement of biliary drainage catheters, as pneumobilia or stent artifact may obscure tumor margins, and the pattern of biliary obstruction may not be evident after decompression. Detection of klatskins tumor in extrahepatic bile duct. How to help a friend with a klatskin tumor diagnosis by dr. Chemotherapy versus surgery in primary bcell lymphoma masquerading as klatskin tumor a diagnostic and therapeutic dilemma. Perihilar bile duct tumors can be further classified as type 1 through type 4, depending on the site of involvement of the ducts. Role of us in the detection, characterization, and staging of. Local resection of hilar tumor, klatskin zollingers atlas. Abstract background the objective of this study was to investigate the incidence, demographics, tumor characteristics, treatment, and survival of patients with hilar cholangiocarcinoma. Discussion klatskin tumor is an adenocarcinoma of the hepatic duct confluence. Perihilar cholangiocarcinomabile duct cancerklatskin.
Demographics, tumor characteristics, treatment, and survival. Klatskin began his association with yale in 1937 and became professor emeritus in 1978. Cholangiocarcinoma is a wellknown complication of primary sclerosing cholangitis psc. A 54yearold man was diagnosed as hilar cholangiocarcinoma klatskin tumor and was administered neoadjuvant and preoperative radiation with chemotherapy. Apr 07, 2020 a klatskin tumor is a tumor which forms in the upper region of the bile duct, where the left and right bile ducts meet. Treatment ofhilar cholangiocarcinoma klatskin tumors with.
Klatskin tumor is a rare hepatobiliary malignancy whose outcome and prognostic factors are not clearly documented. Klatskin tumors classically manifest as segmental dilatation and nonunion of. Klatskin tumour a klatskin tumor or hilar cholangiocarcinoma cancer of the biliary tree occurring at the confluence of the right and left hepatic bile ducts one third of patients are present under the age of 50 years with a male and female predominance 10. Highresolution crosssectional imaging is mandatory for evaluating hilar vasculature prior to any attempt at resection. He is a very sportive, young looking guy, who allways lived a healthy life. Cholangiocarcinoma abbreviated as ccc are malignant growths that arise within the biliary duct system, originating from either the internal side or the external side of the liver, from the extrahepatic bile ducts, and then terminating at the ampulla of vater. Among this almost 60% to 70 % biliary duct cancer is klatskin tumor 1,2. Since that time, cholangiocarcinomas at this location have carried the eponym of klatskin tumors. Now customize the name of a clipboard to store your clips. Because of the rarity of this malignancy, its prognostic risk factors have not been completely analyzed.
It is the most common type of cholangiocarcinoma, accounting for more than half of all cases. Apr 20, 2016 how to help a friend with a klatskin tumor diagnosis by dr. Carcinoma of the hepatic duct bifurcation was first described by altemeir in 1957. Free download brain tumor powerpoint presentation slides. A free powerpoint ppt presentation displayed as a flash slide show on. May 16, 2016 klatskin tumour a klatskin tumor or hilar cholangiocarcinoma cancer of the biliary tree occurring at the confluence of the right and left hepatic bile ducts one third of patients are present under the age of 50 years with a male and female predominance 10. Tumor with spermatic cord metastasis 105 klatskin tumor with spermatic cord metastasis was made. Cholangiocarcinoma klatskin tumour tr, 84 yrs female, bg osteoarthritis admitted with painless obstructive jaundice her symptoms were jaundice, weight loss. Between april 1998 and january 2007, 96 patients with hilar cholangiocarcinoma underwent resection. Kat not real name is a 64yearold indonesian lady from aceh. Klatskinlike lesions hindawi publishing corporation. In 1965 he described the unique features of cholangiocarcinoma at the bifurcation of the main intrahepatic bile ducts, which came to be called the klatskin tumor.
Klatskin tumors manifest with segmental dilatation and disruption of the confluence of the rhd and lhd at the porta hepatis. A klatskin tumor is a tumor which forms in the upper region of the bile duct, where the left and right bile ducts meet. Symptoms usually dont present until advanced stages of disease, when jaundice is the most common feature. Download free medical lung cancer powerpoint presentation. Gerald klatskin 19101986 was born in new york city to a family of russian descent. There may be metastatic nodules throughout the liver with dilation of bile ducts peripheral to the mass. The prevalence of cholangiocarcinoma varies markedly from one geographic region to another, with the highest prevalence in southeast asia, 4, 6. Novel prognostic scoring system after surgery for klatskin. Cholangiocarcinoma ppt free download as powerpoint presentation.
Recent developments in surgical techniques have improved the outcome after resection. Cholangiocarcinoma in primary sclerosing cholangitis. Cholangiocarcinoma staging radiology reference article. The nci dictionary of cancer terms features 8,547 terms related to cancer and medicine. Best biliary drainage option in advanced klatskin tumor.
Customers affiliates powerpointtutorial videotour infographics. Powerpoint is the worlds most popular presentation software which can let you create professional brain cancer powerpoint presentation easily and in no time. I wake up every morning almost in a panic state and its constantly on my mind. We offer a widget that you can add to your website to let users look up cancerrelated terms. Her problems started about three weeks ago when she felt dizzy and had abdominal pain. Curative treatment of klatskin tumors by radical surgical procedures with surgical preparation distant to the tumor region results in 5year survival rates of 3050%.
Definition of klatskin tumor nci dictionary of cancer terms. Free download brain cancer powerpoint presentation slides. The obstruction and subsequent cholestasis tend to occur early if the tumor is located in the common bile duct or common hepatic duct. Mrimrcp with contrast enhancement and delayed imaging i. Tumor involving the confluence of the right and left hepatic ducts is known as klatskin tumor.
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